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Diagnostic Utility of Visual Evoked Potential Changes in Alzheimer's Disease

From the Department of Psychiatry and Behavioral Science at the Mercer University School of Medicine (K.L.C., J.E.A., K.M.E.) and the Department of Psychology, College of Liberal Arts, Mercer University (J.E.A., R.T.A.). Address correspondence to Dr. Coburn, Mercer University School of Medicine, 655 First Street, Macon, GA 31207. E-mail: coburn_kl{at}mercer.edu

Previous studies have consistently found a selective delay of the P2 flash visual evoked potential (VEP) component among groups of patients with Alzheimer's dementia (AD) compared with control groups. Several authors have termed the selective P2 delay a "marker" for AD and have called for its use in clinical diagnosis. This study examined the diagnostic utility of the selective P2 delay in a retrospective sample of 45 AD patients and 60 age-equivalent healthy control subjects. Although significant between-group differences were found, classification accuracies for individual patients and controls were too low for the P2 delay to contribute meaningfully to clinical diagnosis.

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