J Neuropsychiatry Clin Neurosci 15:215-220, May 2003
© 2003 American Psychiatric Press, Inc.
Methamphetamine Dependence Is Associated With Neurocognitive Impairment in the Initial Phases of Abstinence
Ari D. Kalechstein, Ph.D.,
Thomas F. Newton, M.D. and
Michael Green, Ph.D.
Received November 7, 2001; revised February 13, 2002; accepted February 26, 2002. From the Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, School of Medicine. Address correspondence to Dr. Kalechstein, Neuropsychiatric Institute, University of California, Los Angeles, School of Medicine, 760 Westwood Boulevard, Room A7-372, Los Angeles, CA 90024. E-mail: adk{at}ucla.edu
This study documented the association between neurocognitive impairment and methamphetamine dependence in a sample of 27 methamphetamine-dependent individuals who achieved 5 to 14 days of continuously monitored abstinence and in 18 control subjects. Methamphetamine-dependent individuals performed significantly worse than control subjects on neurocognitive measures sensitive to attention/psychomotor speed, on measures of verbal learning and memory, and on executive systems measures sensitive to fluency. These findings are the first to demonstrate that methamphetamine dependence is associated with impairments across a range of neurocognitive domains in a sample of users whose abstinence was continuously monitored with the use of urine screening.
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