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Discontinuation of Antidepressants in Newly Admitted Psychotic Patients

From the Department of Psychiatry, Yale University School of Medicine. Send correspondence to Dr. Bowers, Department of Psychiatry, Yale University School of Medicine, 25 Park Street, New Haven, CT 06515.

ABSTRACT

Antidepressants may exacerbate manic or psychotic symptoms in vulnerable individuals. The authors discontinued antidepressants in 16 consecutive cases in which patients with manic or psychotic symptoms were otherwise judged to be on a satisfactory regimen prior to admission. Thirteen of the patients improved rapidly, which suggests a possible association between antidepressant discontinuation and clinical improvement in this patient group.

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