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Accelerated Memory Decline in Alzheimer's Disease With Apolipoprotein 4 Allele

Received April 3, 2002; revised June 26, 2002; accepted July 11, 2002. From the Departments of Clinical Neurosciences and Basic Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders and Faculty of Health Sciences, Ehime University School of Medicine, Japan. Address correspondence to Dr. Nobutsugu Hirono, Faculty of Health Sciences, Ehime University School of Medicine, Shitsukawa, Shigenobu-Cho, Onsen-gun, 791-0295 Japan; hirono{at}m.ehime-u.ac.jp (E-mail).

To investigate a possible effect of the apolipoprotein (APOE) 4 allele on memory decline in Alzheimer's disease (AD), we examined 64 AD patients with the APOE 3/3, 3/4, or 4/4 allele using the Alzheimer Disease Assessment Scale-Cognitive subscale (ADAS-Cog) and its subtests at the initial examination and at the 1-year follow-up visit. One-year changes in the scores of the Word Recall subtest, Word Recognition subtest, and total ADAS-Cog were significantly correlated with the number of APOE 4 alleles after controlling for the effects of age, sex, education, test interval, and baseline scores. Findings revealed that APOE 4 allele is related to an accelerated memory decline in AD.

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