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* Depression
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J Neuropsychiatry Clin Neurosci 15:422-430, November 2003
© 2003 American Psychiatric Press, Inc.

A Reappraisal of Poststroke Depression, Intra- and Inter-Hemispheric Lesion Location Using Meta-Analysis

K. Narushima, M.D., J. T. Kosier, B.S. and R. G. Robinson, M.D.

Received March 26, 2002; revised July 17, 2002; accepted July 31, 2002. From the Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA; Section of Psychiatry and Behavioral Science, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan; Section of Liaison Psychiatry and Palliative Medicine, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan. Address correspondence to Dr. Robert G. Robinson, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Department of Psychiatry, 2887 JPP, 200 Hawkins Dr., Iowa City, IA 52242; robert-robinson{at}uiowa.edu (E-mail).

A recent publication based on a meta-analysis concluded that there was no association between poststroke depression (PSD) and lesion location. This study, therefore, was undertaken to reappraise the hypothesis using meta-analysis of the correlation between severity of depression following stroke and proximity of the lesion to the frontal pole, an issue that was not examined in the prior meta-analysis. Results showed there was a significant inverse correlation between severity of depression and distance of the lesion from the frontal pole among 163 patients with left hemisphere stroke but not among 106 patients with right hemisphere stroke. This study supports the hypothesis that risk of poststroke depression is related to the location of brain injury.




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