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Cognitive Impairment and Psychiatric Symptoms in 133 Patients With Diseases Associated With Cerebellar Degeneration

Received July 18, 2002; revised September 24, 2002; accepted October 1, 2002. From the Departments of Psychiatry, Neurology, Neuroscience, and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. Portions of this work were presented at the American Neuropsychiatric Society Meeting 2/25–27/2001 and the International Symposium on Mental and Behavioral Dysfunction in Movement Disorders, 10/10–13/2001. Address correspondence to Dr. Margolis, Laboratory of Genetic Neurobiology, Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Meyer 2-181, 600 N. Wolfe St., Baltimore, MD 21287; rmargolis{at}jhmi.edu (E-mail).

ABSTRACT

The authors performed a chart review to determine the frequency with which neurologists detect cognitive and psychiatric symptoms in patients with cerebellar degeneration. Psychopathology, including depression, personality change, cognitive impairment, anxiety, and psychosis was noted in 51% of 133 patients.

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