J Neuropsychiatry Clin Neurosci 16:41-46, February 2004
© 2004 American Psychiatric Press, Inc.
Cavum Septum Pellucidum and Its Increased Prevalence in Schizophrenia: A Neuroembryological Classification
Marcelo Galarza, M.D.,
Alicia B. Merlo, Ph.D.,
Adriana Ingratta, M.D.,
Eduardo F. Albanese, M.D. and
Alfonso M. Albanese, M.D.
Received March 2, 2002; revised September 30, 2002; accepted October 15, 2002. From the Department of Anatomy, Section of Neuroanatomy, School of Medicine, University of Salvador, Buenos Aires, Argentina. Address correspondence to Dr. Galarza, Division of Neurosurgery, Hospital Casa Sollievo della Sofferenza, Viale dei Cappucini 1, 71013, San Giovanni Rotundo, FG, Italy; galarzamarcelo{at}hotmail.com (E-Mail).
Thirty-two female (mean age=52.9 years [SD=9.2]) patients with a diagnosis of residual schizophrenia and 19 female (mean age=51.1 years [SD=12.7]) control subjects were studied through cerebral Magnetic Resonance Imaging. Along the entire surface of the septum pellucidum, 1-mm coronal slices were performed in all subjects. The authors classified the cavum septum pellucidum into three types based on embryological development. The prevalence of a cavum was significantly higher in the patients with schizophrenia (Chi square 6.112. p < 0.05). No other significant associations with previously described morphological brain changes were found. Although this result was found in previous reports (DeGreef et al., 1992; DeLisi et al., 1993), our discussion focused on the neurodevelopmental theory of the septum pellucidum and its possible association with schizophrenia.
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