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Neurometabolic Functioning and Neuropsychological Correlates in Children With ADHD-H: Preliminary Findings

Received March 14, 2003; revised August 13, 2003; accepted September 5, 2003. From the Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry at Johns Hopkins University Medical School, Baltimore; the Department of Radiology and the Clinical Center for the Study of Development and Learning, University of North Carolina, Chapel Hill; and Pinellas County Schools, Florida. Address correspondence to Dr. Courvoisie, Department of Psychiatry and Behavioral Sciences, CMSC 338, Johns Hopkins University Medical School, Baltimore, MD. 21287; hcourvoi{at}jhmi.edu (E-mail).

Proton magnetic resonance spectroscopy (MRS) and neuropsychological testing were conducted on 8 children with attention-deficit/hyperactivity disorder (ADHD-H), with no learning disabilities or comorbidities and 8 controls. Magnetic resonance spectroscopy revealed increased Glutamate/Glutamine in both frontal areas, and increased N-acetyl aspartate and Choline in the right frontal area of the ADHD-H subjects. Neuropsychological testing revealed few within- and between-group differences. Findings related to frontal lobe dysfunction in ADHD-H subjects were noted. N-acetylasparte/creatine (NAA/Creatine) in the right frontal region, and myoinositol/creatine (Myo inositol/Creatine) in the right and left frontal regions appear to be highly associated with the regulation of sensorimotor, language, and memory and learning functioning in children with ADHD-H.

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