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Absence of Cortical Gray Matter Abnormalities in Psychosis of Epilepsy

A Voxel-Based MRI Study in Patients With Temporal Lobe Epilepsy

Received June 18, 2002; revised October 29, 2002; accepted November 18, 2002. From the Raymond Way Research Group, Institute of Neurology, University College London, London, UK; the Department of Psychiatry, University of Freiburg, Germany. Address correspondence to Dr. Tebartz van Elst, Department of Psychiatry, University of Freiburg, Hauptstr. 5, D-79104 Freiburg; ludger_vanelst{at}psyallg.ukl.uni-freiburg.de (E-mail).

The authors retrospectively explored cortical differences between 26 patients with temporal lobe epilepsy and psychosis of epilepsy (POE), 24 patients with temporal lobe epilepsy (TLE) alone, and 20 healthy comparison subjects. Using voxel-based morphometry based on statistical parametric mapping (SPM99), which is an unbiased and fully automated technique to test for morphometric differences, magnetic resonance imaging (MRI) 3D-datasets were acquired and analyzed. There were no significant cortical gray matter differences between the POE and the TLE group. Since cortical pathology is prominent in schizophrenia, POE may be a clinical entity separate from schizophrenia.

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