J Neuropsychiatry Clin Neurosci 16:192-198, May 2004
© 2004 American Psychiatric Press, Inc.
Twenty-Four-Hour Rhythms of Sleep-Wake Cycle and Temperature in Alzheimer's Disease
J. H. Lee, M.D.,
R. Friedland, M.D.,
P. J. Whitehouse, M.D. and
J. I. Woo, M.D.
Received March 6, 2002; revised August 12, 2002; accepted October 15, 2002. From the Department of Psychiatry, Kangwon National University Hospital, Chunchon, Korea; Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea. This work was done in the department of Neurology, Case Western Reserve University School of Medicine, Cleveland, USA, and the department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea. Address correspondence to Dr. Jong Inn Woo, Department of Neuropsychiatry, Seoul National University College of Medicine and Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul, Korea. (110-744), jiwoomd{at}plaza.snu.ac.kr (E-mail).
The authors aimed to examine the difference in 24-hour rhythms of sleep-wake cycle and temperature between Alzheimer's disease (AD) patients and elderly comparison subjects. The continuous measuring of wrist activity and skin temperature was conducted for 96 hours in seven AD patients (age: 77.0±4.3) and 11 normal comparison subjects (age: 74.2±5.2). The mean acrophases and amplitudes of the two rhythms in the AD group were not different from those in the comparison group. The mean phase difference between the two rhythms, however, was significantly lower in the AD group than in the comparison group.
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