J Neuropsychiatry Clin Neurosci 16:199-213, May 2004
© 2004 American Psychiatric Press, Inc.
Neuropsychiatric Practice and Opinion |
Autism and Familial Major Mood Disorder: Are They Related?
Robert DeLong, M.D., D.S.
From the Division of Pediatric Neurology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710. Address correspondence to Dr. DeLong, Division of Pediatric Neurology, Bell Building, Room 141, Duke University Medical Center, Durham, NC 27710.
Family history studies of autism consistently reveal a large subgroup with a high incidence of major mood disorder in family members, suggesting the two entities are related clinically and genetically. This review examines this concept, comparing current clinical and biological knowledge of autism and major mood disorder, and advances the hypothesis that this subgroup of autism represents an early-life phenotype of major mood disorder. If confirmed, this hypothesis would suggest that the basic biological defects determining major mood disorders may have prominent neurodevelopmental and cognitive dimensions. Testing of the hypothesis will depend on genetic studies.
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