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Morphometry of the Superior Temporal Plane In Schizophrenia: Relationship to Clinical Correlates

Received May 29, 2002; revised December 12, 2002; accepted February 3, 2003. From the Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa; the MIND Institute and the University of New Mexico, Albuquerque, New Mexico, and Hospital Universitario Marques de Valdecilla, Santander, Spain. Address correspondence to Dr. Nopoulos, University of Iowa Health Care, Department of Psychiatry, 1-180 MEB, 500 Newton Road, Iowa City, IA 52242-1057; peggy-nopoulos{at}uiowa.edu (E-mail).

A magnetic-resonance-imaging-based method of cortical parcellation was used to evaluate the morphology of the superior temporal plane and its subregions (Heschl's gyrus [HG], planum temporale [PT], and planum polare [PP]) in a group of 30 patients with schizophrenia versus a matched group of healthy subjects. Right HG volume was significantly reduced in patients compared with control subjects. Each subregion showed a unique set of structure/function relationships: reduced volumes of the HG were associated with greater duration of illness; reduced volumes of the PT were associated with positive symptoms; and in most contrast, elevated volumes of the PP were associated with cumulative neuroleptic exposure.

This article has been cited by other articles:

				A. Kopelman, N. C. Andreasen, and P. Nopoulos Morphology of the Anterior Cingulate Gyrus in Patients With Schizophrenia: Relationship to Typical Neuroleptic Exposure Am J Psychiatry, October 1, 2005; 162(10): 1872 - 1878. [Abstract] [Full Text] [PDF]

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