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A Distinctive Interaction Between Chronic Anxiety and Problem Solving in Asymptomatic APOE e4 Homozygotes

Received June 20, 2002; revised; November 6, 2002; accepted November 18, 2002. From the Departments of Neurology, Psychiatry, Psychology, Biostatistics, and Neuroscience, Mayo Clinic Scottsdale, University of Arizona, Tucson, and Arizona State University, Tempe, Arizona. Address correspondence to Dr. Caselli, Department of Neurology, Mayo Clinic Scottsdale, 13400 East Shea Blvd., Scottsdale, AZ 85259, Caselli.Richard{at}Mayo.edu (E-mail).

We correlated measures of problem solving (Wisconsin Card Sorting Test [WCST] categories, total errors, and perseverative errors) and chronic anxiety (Personality Assessment Inventory Anxiety Scale [ANX]) in asymptomatic apolipoprotein E (APOE) e4 homozygotes (HMZs), heterozygotes, and noncarriers (NC) (n= 42 in each group) matched for age, education, and gender. Differences between HMZ and NC in the slope of the regression of WCST scores on ANX reached statistical significance on all three WCST measures. Chronic anxiety adversely affects cognitive skills in all groups, and is associated with significantly greater decline in problem solving skills in cognitively normal APOE e4 HMZ.

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				R. J. Caselli, E. M. Reiman, D. E. C. Locke, M. L. Hutton, J. G. Hentz, C. Hoffman-Snyder, B. K. Woodruff, G. E. Alexander, and D. Osborne Cognitive Domain Decline in Healthy Apolipoprotein E {varepsilon}4 Homozygotes Before the Diagnosis of Mild Cognitive Impairment Arch Neurol, September 1, 2007; 64(9): 1306 - 1311. [Abstract] [Full Text] [PDF]

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