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Volumetric Investigation of the Frontal-Subcortical Circuitry in Patients With Obsessive-Compulsive Disorder

Received September 24, 2002; revised February 10, 2003; accepted February 26, 2003. From the Department of Psychiatry, Department of Radiology, BK 21 Human Life Science, Seoul National University College of Medicine, Seoul, Korea; Clinical Research Institute, Seoul National University Hospital, Seoul, Korea; Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea. Address for Correspondence: Dr. Kwon, Department of Psychiatry and Nuclear Medicine, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul, Korea 110-744; kwonjs{at}plaza.snu.ac.kr (E-mail).

The pathophysiology of obsessive-compulsive disorder (OCD) is thought to involve disturbance of the frontal-subcortical circuitry. To investigate the morphological characteristics of this circuitry, we examined the volume of the orbitofrontal cortex, anterior cingulate, thalamus, caudate, and the putamen in 36 age- and sex-matched OCD patients and normal control subjects using three-dimensional magnetic resonance (MR) brain imaging. The left orbitofrontal volumes were found to be significantly smaller in the OCD patients and showed significant negative correlations with obsessive-compulsive symptom severity. These findings suggest that a structural abnormality of this brain region is implicated in the pathophysiology of OCD.

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