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SPECT Imaging of Body Dysmorphic Disorder

Received October 3, 2001; revised February 10, 2003; accepted February 26, 2003. From the MRC Unit for Stress and Anxiety Disorders, University of Stellenbosch; Department of Nuclear Medicine, University of Stellenbosch; Department of Psychiatry, University of Florida, Gainesville. Address correspondence to Dr. Carey, MRC Unit for Stress and Anxiety Disorders, University of Stellenbosch, P.O. Box 19063, Tygerberg, Cape Town, South Africa; pcarey{at}sun.ac.za (E-mail).

ABSTRACT

[99mTc]Hexamethylpropylene amine oxime (HMPAO) single photon emission computed tomography (SPECT) brain scans were undertaken in six subjects with body dysmorphic disorder (BDD). The scans showed a broad range of discrepant findings that do not immediately support a view of BDD as resting on either an obsessive-compulsive or affective disorder spectrum. Nevertheless, involvement of parietal regions is consistent with the characteristic altered body perception of BDD. These preliminary data highlight the need for further systematic functional imaging studies of this condition.

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