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One-Year Change in Cerebral Glucose Metabolism in Patients With Alzheimer's Disease

Received October 10, 2002; revised February 10, 2003; accepted February 26, 2003. From the Department of Psychology, Kobegakuin University, 518 Arise, Ikawadani, Nishi-Ku, Kobe, Japan; the Departments of Clinical Neurosciences and Neuroimaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders and Faculty of Health Sciences, Ehime University School of Medicine. Address correspondence to Dr. Hirono, Department of Psychology, Kobegakuin University, 518 Arise, Ikawadani, Nishi-Ku, Kobe, 651-2180, Japan hirono{at}human.kobegakuin.ac.jp (E-mail).

By using [¹⁸F]-2-fluoro-deoxy-D-glucose and positron emission tomography, the authors studied changes in regional glucose metabolism after a 1-year interval in patients with mild Alzheimer’s disease (AD). Glucose metabolism declined over time in the bilateral precuneus and posterior cingulate gyri and in the frontal, temporal, and parietal cortices. Glucose metabolism in these regions may be a useful measure of the progression of AD and a valid surrogate outcome measure of clinical drug trials.

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