J Neuropsychiatry Clin Neurosci 16:500-504, November 2004
© 2004 American Psychiatric Press, Inc.
Clinical and Research Reports |
Neuropsychiatric Sequelae of Nipah Virus Encephalitis
Beng-Yeong Ng, M.B.B.S., M.Med. (Psych.),
C.C. Tchoyoson Lim, M.B.B.S., M.Med. (Diag. Radiol.), F.R.C.R.,
Alice Yeoh, B.A. (Hons.) Psych., M.Clin.Psych. and
W.L. Lee, M.M.B.S. (Hons.), M.R.C.P. (U.K.), F.R.C.P. (Edin.), M.Med. (Paed.)
Received September 9, 2002; revised March 24, 2003; accepted April 15, 2003. From Department of Behavioral Medicine, Singapore General Hospital; Consultant Neuroradiologist, Department of Neuroradiology, National Neuroscience Institute, Singapore; Clinical Psychologist, Tan Tock Seng Hospital, Singapore; Senior Consultant Neurologist, National Neuroscience Institute, Singapore. Address correspondence to Dr. Yeong, Department of Behavioral Medicine, Singapore General Hospital, Outram Rd., Singapore 169608, Republic of Singapore; gdmnby{at}sgh.com.sg (E-mail).
ABSTRACT
The authors followed nine patients with Nipah virus encephalitis over the course of 24 months. Eight of the nine developed psychiatric features assigned to the encephalitis. Three patients developed major depressive disorder immediately after recovering from the encephalitis, and two developed depression approximately 1 year after the outbreak. Two patients developed personality changes, and two suffered chronic fatigue syndrome. Neuropsychological testing was accomplished in eight of the nine patients. Deficits in attention, verbal, and/or visual memory were substantial in seven of the eight patients tested. Verbal memory was more impaired than visual memory in these patients. Comparison between psychiatric and cognitive impairment and total number of brain lesions showed no discernible trends.
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