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Cognitive Impairment Associated With Major Depression Following Mild and Moderate Traumatic Brain Injury

Received April 11, 2003; revised June 10, 2003; accepted July 17, 2003. From the Department of Psychiatry and Traumatic Brain Injury Clinic, Sunnybrook and Women’s College Health Sciences Centre, University of Toronto, Toronto, Ontario. Department of Psychology, Baycrest Centre for Geriatric Care, Toronto, Ontario. Address correspondence to Dr. Rapoport, FG37, Sunnybrook and Women’s College Health Sciences Centre, 2075 Bayview Ave., Toronto, ON, M4N 3M5, 416-480-4085; Mark.Rapoport{at}sw.ca (E-mail).

Traumatic brain injury (TBI) and major depression are neuropsychiatric conditions that have been associated with cognitive dysfunction. The aim of this study was to explore the relationship between major depression and cognitive impairment following mild and moderate TBI. Seventy-four TBI patients were assessed for the presence of major depression using the Structured Clinical Interview for the DSM-IV and completed a neurocognitive assessment battery. Subjects with major depression (28.4%), compared to those without, were found to have significantly lower scores on measures of working memory, processing speed, verbal memory and executive function. Potential mechanisms and implications for treatment are discussed.

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