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Increasing Memory Load Modulates Regional Brain Activity in Older Adults as Measured by fMRI

Received March 13, 2003; revised September 23, 2003; accepted February 10, 2004. From the Department of Radiology and Brain Imaging and Analysis Center and the Department of Psychiatry, Duke University Medical Center, Durham, North Carolina; the Department of Psychology, University of Pennsylvania, Philadelphia; the Department of Psychiatry, Naval Medical Center, San Diego, California; the Department of Psychology, Washington University, St. Louis, Missouri.; and the Department of Psychology, University of North Carolina, Chapel Hill, North Carolina. Address correspondence to Dr. Petrella, Department of Radiology, DUMC, Box 3808, Durham NC 27710-3808; Jeffrey.Petrella{at}duke.edu (E-mail).

Several recent studies using functional magnetic resonance imaging (fMRI) during recognition memory tests have suggested that the ability to neuromodulate as a function of cognitive demand may be impaired in older adults due to age-related cell loss and neural volume reduction in memory specific regions. In the current study, older adults (ages 59–77) were tested with fMRI during a delayed-recognition task in which memory load for faces was varied across trials. Activity was greater in amplitude for three- versus one-face stimuli within the superior, middle, and inferior frontal gyri, intraparietal sulcus, and fusiform gyrus. It was concluded that the ability to modulate activity with increasing load is preserved in older adults despite reductions in neural volume.

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