Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Weitzner, M. A. Articles by Booth-Jones, M. Search for Related Content PubMed Citation Articles by Weitzner, M. A. Articles by Booth-Jones, M. Other Mood Disorders Other Neuroanatomy

Apathy and Pituitary Disease: It Has Nothing to Do With Depression

Received September 30, 2002; revised July 7, 2003; accepted July 24, 2003. From the Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, Tampa, Florida; and the Psychosocial and Palliative Care Program, H. Lee Moffitt Cancer Center, Tampa, Florida. Address correspondence to Dr. Weitzner, Medical Director, Helios Pain & Psychiatry Center, 3262 Cove Bend Dr., Tampa, FL 33613; mweitzner{at}helioscenter.net (E-mail).

Increasingly, patients with pituitary disease are evaluated and treated at cancer centers. In many ways, these patients resemble patients with other malignant brain tumors. Although the majority of pituitary adenomas are benign, the physical, emotional, and cognitive changes that these patients experience on their well-being is malignant. Pituitary disease causes a variety of physical illnesses resulting from the alterations in the hypothalamic-pituitary-end organ axis. In addition, patients with pituitary diseases may experience many emotional problems, including depression, anxiety, behavioral disturbances, and personality changes, above and beyond the many reactions these patients may have to the myriad of adjustments that they must make in their lives. There is a growing understanding that pituitary patients may experience these emotional problems as a result of long-term effects that the pituitary tumor itself, treatment, and/or hormonal changes have on the hypothalamic-pituitary-end organ axis. The authors present a series of cases, in which patients with pituitary disease were diagnosed and treated for depression and showed little response to the treatment for depression. When the diagnosis of apathy syndrome was considered and treatment implemented, the patients’ condition improved. A review of the literature on apathy, hypothalamic-pituitary-end organ axis dysfunction, and treatment for apathy syndrome is included.

This article has been cited by other articles:

				C Sievers, M Ising, H Pfister, C Dimopoulou, H J Schneider, J Roemmler, J Schopohl, and G K Stalla Personality in patients with pituitary adenomas is characterized by increased anxiety-related traits: comparison of 70 acromegalic patients with patients with non-functioning pituitary adenomas and age- and gender-matched controls Eur. J. Endocrinol., March 1, 2009; 160(3): 367 - 373. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2005 American Neuropsychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us