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The Relationship Between Age and Cognitive Function in HIV-Infected Men

Received September 12, 2002; revised November 21, 2003; accepted November 26, 2003. From the Department of Psychiatry, Ohio State University College of Medicine and Public Health, Columbus, Ohio. Address correspondence to Dr. Bornstein, Neurosciences Facility, 1670 Upham Dr., Suite 130, Columbus, OH 43210-1252; bornstein.1{at}osu.edu (E-mail).

Several studies have identified increased age as a risk factor for the development of cognitive impairment in human immunodeficiency virus (HIV)-infected subjects, but few have examined the potential synergistic effect of age and HIV serostatus on cognitive decline. The authors examined the possible combined effect of age and HIV serostatus on cognitive decline in 254 subjects stratified by age group and HIV status. After controlling for the effect of education, there were significant effects for serostatus and age group on overall cognitive impairment and a number of neuropsychological measures but no interaction effects. These data suggest that older seropositive individuals are not at an increased risk for HIV-related cognitive impairment when normal age-related cognitive changes are considered.

Key Words: HIV Infection • Cognitive Function • Age

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