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HIV Dementia Scale and Psychomotor Slowing—The Best Methods in Screening for Neuro-AIDS

Received May 16, 2003; revised June 5, 2003; accepted March 23, 2004. From the Department of Neurology, Heinrich Heine University Düsseldorf, Germany. Address correspondence to Dr. von Giesen, Department of Neurology, Heinrich Heine University Düsseldorf, Postfach 10 10 07 D-40001 Düsseldorf, Germany; giesenhj{at}uni-duesseldorf.de (E-mail).

The authors examined the correlation between Human Immunodeficiency Virus (HIV) Dementia Scale (HDS) and psychomotor tests, evaluating basal ganglia function in 266 HIV-seropositive, Caucasian, homosexual men. Fifty-five HIV-positive, patients with mild dementia (HDS score 10) showed significant slowing of most rapid alternating movements (MRAM) and significantly prolonged contraction times compared to 211 HIV-positive nondemented patients (HDS score >10). Motor performance correlated significantly with the time-dependent HDS subscores for psychomotor speed and construction and HDS sum score. In contrast to contraction times and MRAM, HDS scores also showed significant correlations to age, premorbid and actual intelligence, and duration of HIV seropositivity.

Key Words: HIV-1 • HIV-1 associated dementia • central nervous system • psychomotor slowing • HIV dementia scale • screening

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				J. Robinson-Papp, D. Byrd, M. R. Mindt, N. L. Oden, D. M. Simpson, S. Morgello, and for the Manhattan HIV Brain Bank Motor Function and Human Immunodeficiency Virus-Associated Cognitive Impairment in a Highly Active Antiretroviral Therapy-Era Cohort Arch Neurol, August 1, 2008; 65(8): 1096 - 1101. [Abstract] [Full Text] [PDF]

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