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H₂¹⁵O PET Study of Impairment of Nonverbal Recognition With Normal Aging

Received October 23, 2002; revised October 2, 2003; accepted February 4, 2004. From the Departments of Neurology, Psychiatry and Radiology, and the Cognitive Neuroscience Division of the Sergievsky Center, College of Physicians and Surgeons of Columbia University, New York, New York; the Alzheimer’s Disease Research Center in the City of New York, New York; and the Department of Biological Psychiatry, New York State Psychiatric Institute, New York, New York. Address correspondence to Dr. Yaakov Stern, Cognitive Neuroscience Division of the Sergievsky Center, Columbia University, 630 West 168th St, P&S Box 16, New York, NY 10032.

Little research has been conducted regarding age-related changes in nonverbal memory. Using positron emission tomography (PET), the authors studied 17 elderly volunteers and 20 young volunteers, during nonverbal recognition task performance, to examine differences in brain blood flow. The subjects were asked to recognize a study list size (SLS) of shapes that was adjusted so that each subject performed at approximately 75% accuracy. Positron emission tomography results showed that, relative to younger individuals, elderly subjects engaged different regions, including the insula, during recognition. Elderly subjects did not show the relationship between parahippocampal flow and SLS, which was observed in younger subjects. These differences suggest that age-related functional brain changes partly explain performance deficits.

Key Words: Brain Imaging • Normal Aging • Nonverbal Memory

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