J Neuropsychiatry Clin Neurosci 17:239-242, May 2005
© 2005 American Psychiatric Press, Inc.
Clinical and Research Reports |
Relation Between Estradiol and Negative Symptoms in Men With Schizophrenia
Y. Kaneda, M.D., Ph.D. and
T. Ohmori, M.D., Ph.D.
Received June 24, 2003; revised November 5, 2003; accepted November 26, 2003. From the Department of Psychiatry, Tokushima University Hospital, Tokushima, Japan; and the Psychopharmacology Division, Psychiatric Hospital at Vanderbilt, Nashville, Tennessee. Address correspondence to Dr. Kaneda, Department of Psychiatry, Tokushima University Hospital, 3-18-15 Kuramoto-Cho,Tokushima, Tokushima 770-8503, Japan; kaneday-tsh{at}umin.ac.jp (E-mail).
ABSTRACT
The authors tested the hypothesis that estradiol would be associated with negative symptoms in 30 male schizophrenia inpatients. Medications were switched from typical to atypical antipsychotics. Estradiol concentrations were inversely correlated with negative symptoms significantly before the switch and at a trend level of significance after the switch. Changes in negative symptoms were positively correlated with those in estradiol concentrations at a trend level of significance. Estradiol could be a biological marker for negative symptoms even in male schizophrenia patients.
Key Words: Anipsychotic agents • Estradiol • Men • Psychotic symptoms • Schizophrenia
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