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Prevalence and Treatment of Depression in Parkinson’s Disease

Received September 12, 2003; revised January 21, 2004; accepted April 5, 2004. From the Houston Center for Quality of Care and Utilization Studies, Health Services Research and Development Service, VA Medical Center, Houston, Texas; the Houston Veterans Affairs Parkinson’s Disease Research, Education, and Clinical Center, Houston, Texas; Baylor College of Medicine, Department of Neurology, Houston, Texas; Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, Texas; the South Central Mental Illness Research, Education, & Clinical Center (MIRECC). Address correspondence to Dr. Kunik, Houston Center for Quality of Care and Utilization Studies, Veterans Affairs Medical Center (152), 2002 Holcombe Blvd., Houston, TX 77030; mkunik{at}bcm.tmc.edu (E-mail).

Parkinson’s disease (PD) is a progressive neurological condition with debilitating symptoms, and depression is a common comorbid condition of this disease. The authors review existing literature on the prevalence and treatment of depression in PD. Prevalence estimates of depression vary widely, ranging from 7%–76%. This variation is due to inconsistent methodology. Treatment options for depression in PD include medication therapy, electroconvulsive therapy (ECT), and psychotherapy. There are few randomized controlled trials of these treatment options. The authors argue for more systematic and controlled research examining both the prevalence and treatment of depression in PD.

Key Words: Parkinson’s Disease • Depression • Prevalence

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