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Proteomic Analysis of Corticobasal Degeneration: A Case Study of Corticobasal Degeneration at the Proteome Level

Received April 30, 2003; revised September 28, 2004; accepted November 2, 2004. From the National Key Laboratory of Protein Engineering, College of Life Sciences, Peking University, Beijing 100871, P.R. China. Address correspondence to Binggen Ru; and the Department of Pharmacology and Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY. rulab{at}pku.edu.cn (E-mail).

Corticobasal degeneration (CBD) is an adult-onset progressive neurodegenerative disorder. However, its pathogenic mechanisms underlying this disorder remain poorly understood. The authors examined changes of proteome profiles between three nondemented comparison brains and a CBD brain based on two-dimensional gel electrophoresis. Two up-regulated proteins in the CBD brain were identified as protein-L-isoaspartate (D-aspartate) O-methyltransferase and cofilin 1 (non-muscle), and six down-regulated proteins were identified as carbonyl reductase [NADPH] 1, two of peptidyl-prolyl cis-trans isomerase A, ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphoglycerate mutase 1 (brain) and chain A of human peroxiredoxin 5. Subsequently, the possible relevance of these changes was analyzed.

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