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J Neuropsychiatry Clin Neurosci 17:384-390, August 2005
doi: 10.1176/appi.neuropsych.17.3.384
© 2005 American Neuropsychiatric Association
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* Schizophrenia Spectrum Disorders

Symptom-Oriented Versus Syndrome Approaches to Resolving Heterogeneity of Neuropsychological Functioning in Schizophrenia

Alex S. Cohen, Ph.D. and Nancy M. Docherty, Ph.D.

Received August 26, 2003; revised June 8, 2004; accepted June 11, 2004. From the Department of Psychology, University of Maryland, College Park, Maryland. Address correspondence to Alex Cohen, Ph.D., University of Maryland, Department of Psychology, 1129 Biology/Psychology Bldg., College Park, MD 20742; acohen{at}psyc.umd.edu (E-mail).

Schizophrenia is a heterogeneous disorder. The syndrome and the symptom-oriented approaches are two methods that have been used to examine differences in psychopathological processes across different patients with schizophrenia. The authors indirectly compared these two approaches in their examination of associations between positive symptoms and neuropsychological performance. Positive syndrome and delusion and hallucination severity scores were compared in respective associations to functioning on 12 neuropsychological variables in 73 stable outpatients with schizophrenia. The individual symptoms of the positive syndrome were associated with relatively distinct patterns of neuropsychological performance, suggesting that the symptom-oriented approach was more sensitive.

Key Words: Schizophrenia • Neuropsychology • Syndrome • Symptom







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