Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Silver, H. Articles by Feldman, P. Search for Related Content PubMed Citation Articles by Silver, H. Articles by Feldman, P. Schizophrenia Spectrum Disorders

Evidence for Sustained Attention and Working Memory in Schizophrenia Sharing a Common Mechanism

Received July 15, 2003; revised April 18, 2004; accepted April 22, 2004. From the Brain Behavior Laboratory, Sha’ar Menashe Mental Health Center, Mobile Post Hefer 38814, Israel; the Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel. Address correspondence to Dr. Silver, Deputy Director, Sha’ar Menashe Mental Health Center, And Director, Brain Behavior Laboratory, Mobile Post Hefer 38814, Israel; mdsilver{at}tx.technion.ac.il (E-mail).

Sustained attention and working memory (WM) are closely related functions that may share common mechanisms. The authors assessed sustained attention in schizophrenia patients and healthy comparison subjects using visuomotor tracking tasks under varying distractor loads. The attentional effort expended to deal with distractors was lower in patients and showed significant association with WM, executive function and negative symptoms in that group. It is proposed that the anterior attention system of sustained attention models and the executive function of the WM model describe the same or a closely related mechanism that is located in the prefrontal cortex (PFC) and is impaired in schizophrenia.

This article has been cited by other articles:

				H. M. Morris, T. Hashimoto, and D. A. Lewis Alterations in Somatostatin mRNA Expression in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia or Schizoaffective Disorder Cereb Cortex, July 1, 2008; 18(7): 1575 - 1587. [Abstract] [Full Text] [PDF]

				G. D. Honey, P. R. Corlett, A. R. Absalom, M. Lee, E. Pomarol-Clotet, G. K. Murray, P. J. McKenna, E. T. Bullmore, D. K. Menon, and P. C. Fletcher Individual Differences in Psychotic Effects of Ketamine Are Predicted by Brain Function Measured under Placebo J. Neurosci., June 18, 2008; 28(25): 6295 - 6303. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2005 American Neuropsychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us