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Dose Effects of Modafinil in Sustaining Wakefulness in Narcolepsy Patients With Residual Evening Sleepiness

Received October 8, 2003; revised May 6, 2004; accepted May 7, 2004. From the Integris Southwest and Baptist Medical Centers, Oklahoma City, Oklahoma; Palms of Pasadena Hospital, St. Petersburg, Florida; and the Baptist Medical Center, Columbia, South Carolina. Address correspondence to Dr. Schwartz, Integris Sleep Disorders Center of Oklahoma, Integris Southwest and Baptist Medical Centers, 4200 S. Douglas, Suite 313, Oklahoma City, OK 73109; SchwJR{at}integris-health.com (E-mail).

Excessive sleepiness associated with narcolepsy lasts throughout the waking day. The authors conducted two randomized, double-blind studies to compare the efficacy of modafinil once-daily versus split doses in maintaining wakefulness throughout the day. Fifty-six patients received modafinil. The split-dose regimens were significantly more effective than the 200-mg once-daily regimen for sustaining wakefulness in the late afternoon/evening. All modafinil dosing regimens were well tolerated. In patients who experience excessive sleepiness in the late afternoon/evening, despite satisfactory treatment earlier in the day, a split dose of modafinil may promote wakefulness throughout the waking day.

Key Words: Narcolepsy • sleepiness • wakefulness • modafinil • dose-response relationship

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				B. K. Madras, Z. Xie, Z. Lin, A. Jassen, H. Panas, L. Lynch, R. Johnson, E. Livni, T. J. Spencer, A. A. Bonab, et al. Modafinil Occupies Dopamine and Norepinephrine Transporters in Vivo and Modulates the Transporters and Trace Amine Activity in Vitro J. Pharmacol. Exp. Ther., November 1, 2006; 319(2): 561 - 569. [Abstract] [Full Text] [PDF]

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