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Loss of Insight and Functional Neuroimaging in Frontotemporal Dementia

Received July 15, 2003; revised January 4, 2004; accepted March 16, 2004. From the Departments of Neurology and Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California. Address correspondence to Dr. Mendez, Neurobehavior Unit (116AF), VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, CA 90073; mmendez{at}UCLA.edu (E-mail).

ABSTRACT

Loss of insight is a diagnostic criterion for frontotemporal dementia. It is associated with hypoperfusion/hypometabolism in the right hemisphere, particularly the frontal lobe. Loss of insight is often an anosodiaphoria (i.e., lack of concern) rather than an anosognosia (i.e., decreased awareness).

Key Words: Anosognosia • insight • dementia • frontotemporal dementia • Alzheimer’s disease

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