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Neuropsychiatric Associations of Apolipoprotein E Alleles in Subjects With Combat-Related Posttraumatic Stress Disorder

Received April 19, 2004; revised June 22, 2004; accepted June 25, 2004. From the Mental Health Service, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas; South Central MIRECC; University of Arkansas Medical Sciences Department of Psychiatry, Little Rock, Arkansas; University of Arkansas Medical Sciences Department of Geriatrics, Little Rock, Arkansas; Geriatric, Research, Education, and Clinical Centers; Donald W. Reynolds Center on Aging. Address correspondence to Dr. Freeman, North Little Rock PTSD Program, North Little Rock VAMC, Mail Code: 116AP/NLR, 2200 Fort Roots Dr., North Little Rock, AR 72114; THOMAS.FREEMAN{at}MED.VA.GOV (E-mail).

ABSTRACT

Previous studies have reported associations between apolipoprotein E (APOE) genotype, cognitive function, and psychopathology in psychiatric populations. The authors investigated the associations between APOE allele status, memory function, and posttraumatic stress disorder (PTSD) symptom severity in PTSD subjects. Presence of the APOE 2 allele was associated with significantly worse reexperiencing symptoms and impaired memory function in this population.

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