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Acquired Extroversion Associated With Bitemporal Variant of Frontotemporal Dementia

Received June 14, 2004; revised August 9, 2004; accepted August 16, 2004. From the Departments of Neurology and Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles California. Address correspondence to Dr. Mendez, Neurobehavior Unit (116AF), VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, CA 90073; mmendez{at}ucla.edu (E-mail).

ABSTRACT

Frontotemporal dementia (FTD) is characterized by alterations in personality. The nature of the personality changes depend on the localization of the pathology. The authors present three patients with acquired extroversion who met criteria for FTD. All three patients exhibited predominant bilateral temporal involvement as determined with functional neuroimaging. Possible mechanisms for acquired extroversion in bitemporal FTD include bilateral amygdalar damage with decreased interpersonal fear or sense of threat, orbitofrontal-ventromedial damage with social disinhibition, and relative sparing of dorsolateral frontal and anterior cingulate regions with preserved interpersonal agency. FTD can be a vehicle for unraveling the basis of personality characteristics such as the introversion/extroversion dimension.

This article has been cited by other articles:

				M. F. Mendez, E. C. Lauterbach, S. M. Sampson, and ANPA Committee on Research An Evidence-Based Review of the Psychopathology of Frontotemporal Dementia: A Report of the ANPA Committee on Research J Neuropsychiatry Clin Neurosci, May 1, 2008; 20(2): 130 - 149. [Abstract] [Full Text] [PDF]

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