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Family History of Dementia: Dementia With Lewy Bodies and Dementia in Parkinson’s Disease

Received July 29, 2004; revised December 9, 2004; accepted December 14, 2004. From the Department of Neurology, University of Miami, Miller School of Medicine, National Parkinson Foundation (NPF), Miami, Florida. Address correspondence to Dr. Papapetopoulos, Dept. of Neurology, University of Miami, Miller School of Medicine, Rm. 4004, 1501 NW 9th Ave, Miami Fl, 33136; spapapetropoulos{at}med.miami.edu (E-mail).

ABSTRACT

Parkinson’s disease with dementia (PD-D) and dementia with Lewy bodies (DLB) may result from the same neurodegenerative process with different temporal and spatial courses. The authors report an association between DLB and family history of dementia in a comparison study between patients with a clinicopathological diagnosis of PD-D and DLB. Findings suggest that positive family history for dementia is associated with DLB with a yet unknown mechanism.

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