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Serotonin Transporter Gene Promoter Region Polymorphism Associated With Poststroke Major Depression

Received September 24, 2004; revised August 3, 2005; accepted August 9, 2005. From the Departments of Psychiatry, Clinical Neurosciences, and Medical Genetics, University of Calgary., Alberta, Canada. Address correspondence to Dr. Ramasubbu, Department of Psychiatry and Clinical Neurosciences, University of Calgary, Special Services Building, Rm. AW258A, 1403, 29th Street N.W., Calgary, Alberta, Canada, T2N 2T9; rramasub{at}ucalgary.ca (E-mail).

ABSTRACT

The authors examined variations of serotonin transporter-linked promoter region (5-HTTLPR) functional polymorphism in 26 stroke patients with major depression and in 25 unrelated nondepressed stroke subjects of Caucasian descent. Findings indicate a significant association between 5-HTTLPR short variant genotype and poststroke major depression.

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