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Dementia With Mood Symptoms in a Fragile X Premutation Carrier With the Fragile X-Associated Tremor/Ataxia Syndrome: Clinical Intervention With Donepezil and Venlafaxine

Received April 20, 2004; revised August 4, 2004; accepted May 6, 2005. From the Departments of Psychiatry and Behavioral Sciences, Radiology, Biochemistry and Molecular Medicine, Neurology, and Pediatrics, University of California, Davis, Medical Center, Sacramento, California; and the M.I.N.D. Institute, University of California, Davis, Medical Center, Sacramento, California. Address correspondence to Dr. Bourgeois, University of California, Davis, Medical Center, Department of Psychiatry and Behavioral Sciences, 2230 Stockton Blvd., Sacramento CA 95817; james.bourgeois{at}ucdmc.ucdavis.edu (E-mail).

The authors present a case of a patient with dementia with mood symptoms and multiple neurological manifestations of fragile X-associated tremor/ataxia syndrome (FXTAS). Despite a gradually deteriorating neurological course, he was managed for 2 years with combination therapy of donepezil and venlafaxine, which resulted in improvement and relative stabilization of his psychiatric status. Psychiatrists are hereby alerted to the description of a novel dementia syndrome that may respond to pharmacological intervention commonly used for other dementias.

This article has been cited by other articles:

				K. Amiri, R. J. Hagerman, and P. J. Hagerman Fragile X Associated Tremor/Ataxia Syndrome: An Aging Face of the Fragile X Gene Arch Neurol, January 1, 2008; 65(1): 19 - 25. [Full Text] [PDF]

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