Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Chen, X. Articles by Schultz, S. K. Search for Related Content PubMed Citation Articles by Chen, X. Articles by Schultz, S. K. Cognition

Donepezil Effects on Cerebral Blood Flow in Older Adults With Mild Cognitive Deficits

Received January 24, 2005; revised April 24, 2005; accepted May 16, 2005. From the Roy J. and Lucille A. Carver College of Medicine, Departments of Radiology and Psychiatry, Iowa City, Iowa. Address correspondence to Dr. Schultz, Psychiatry Research, 2-207 Medical Education Building, The Roy J. and Lucille A. Carver College of Medicine, 500 Newton Rd., Iowa City, IA 52242-1000; susan-schultz{at}uiowa.edu (E-mail).

Cerebral blood flow (CBF) was assessed during a verbal recall task using [¹⁵O]water positron emission tomography (PET) in older adults with mild cognitive deficits participating in a placebo-controlled donepezil trial. The placebo group demonstrated reduced CBF in the left frontal and temporal regions over the 6-month period, while those receiving donepezil did not. The placebo group’s performance did not change on a list-learning task, while the donepezil group’s performance improved, despite having had lower performance at intake. These findings suggest that donepezil treatment may be associated with a relative maintenance of CBF and improved list-learning.

This article has been cited by other articles:

				S. Vale Current Management of the Cognitive Dysfunction in Parkinson's Disease: How Far Have We Come? Experimental Biology and Medicine, August 1, 2008; 233(8): 941 - 951. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2006 American Neuropsychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us