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Apolipoprotein E Genotype and Odor Identification in Schizophrenia

Received November 6, 2004; revised January 31, 2005; accepted February 11, 2005. From the Schizophrenia Research Center, Department of Psychiatry; Smell and Taste Center, Department of Otorhinolaryngology: Head & Neck Surgery; Center for Neurobiology and Behavior, Department of Psychiatry; University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Address correspondence to Dr. Moberg. Brain-Behavior Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce St., Philadelphia, PA 19104; moberg{at}bbl.med.upenn.edu (E-mail).

ABSTRACT

The authors examined Apolipoprotein E (ApoE) genotype frequencies and unirhinal odor identification in 28 schizophrenia patients and 26 healthy comparison subjects. No significant associations between ApoE status and olfaction were observed in either diagnostic group. The authors concluded that olfactory deficits in schizophrenia do not appear to be mediated by the ApoE allele.

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