Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via Google Scholar Articles by Roalf, D. R. Articles by Moberg, P. J. Search for Related Content PubMed Citation Articles by Roalf, D. R. Articles by Moberg, P. J. Schizophrenia Spectrum Disorders

Unirhinal Olfactory Function in Schizophrenia Patients and First-Degree Relatives

Received April 25, 2005; revised July 25, 2005; accepted August 23, 2005. All authors are affiliated with the Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Drs. Turetsky and Moberg are also affiliated with the Smell and Taste Center, Department of Otorhinolaryngology: Head & Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Dr. Brensinger is affiliated with the Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Address correspondence to Dr. Moberg, Brain-Behavior Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce St., Philadelphia, PA 19104. moberg{at}bbl.med.upenn.edu (E-mail).

Previous studies report birhinal impairments in odor identification in patients with schizophrenia and their family members. The authors employed unirhinal odor identification and detection threshold sensitivity tests in schizophrenia patients, healthy first-degree family members, and healthy comparison subjects. Patients and family members showed deficits in odor identification performance in both nostrils. Odor detection thresholds differed only between patients and healthy comparison subjects. Comparable odor identification deficits in both patients and healthy family members suggest that odor identification measures may serve as a sensitive endophenotypic vulnerability marker and that unirhinal olfactory measures are as precise, if not more so, than birhinal performance measures.

Get information about faster international access.

Privacy Policy

Copyright © 2006 American Neuropsychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us