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Mid-Latency Auditory-Evoked Responses and Sensory Gating in Focal Epilepsy: A Preliminary Exploration

Received November 10, 2005; revised April 21, 2006; accepted April 24, 2006. Drs. Boutros, Korzyukov, and Burroughs are affiliated with Wayne State University, School of Medicine, Department of Psychiatry and Behavioral Neurosciences, Detroit, Michigan. Drs. Trautner, Elger, and Rosburg are affiliated with the Department of Epilepsy, University of Bonn, Germany. Dr. Grunwald is affiliated with Zurich Epilepsy Center, Zurich, Switzerland. Dr. Kurthen is affiliated with the Department of Epilepsy, University of Bonn, Germany, and Zurich Epilepsy Center, Zurich, Switzerland. Address correspondence to Dr. Boutros, Wayne State University School of Medicine, UPC-Jefferson. 2751 E. Jefferson, Suite 305, Detroit, MI 48207; nboutros{at}med.wayne.edu (E-mail).

ABSTRACT

The relationship between epilepsy and psychosis is not well defined. Sensory gating is a possible endophenotype for psychosis, and has not been fully examined in epileptic patients. The authors examined 29 patients with focal epilepsy who were on antiepileptic medications, and 29 age-matched healthy comparison subjects, using a paired-stimulus (S1-S2) paradigm. P50 and N100 amplitudes or gating did not differ between the groups. The P200 was significantly smaller and did not gate as well in epileptic patients. Though alteration of sensory gating can be demonstrated in epileptic patients, it seems to be qualitatively different from alterations reported in association with schizophrenia.

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