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Depressive and Memory Symptoms as Presenting Features of Spinocerebellar Ataxia

Received November 7, 2005; accepted November 21, 2005. Drs. McMurtray, Clark, and Mendez are affiliated with the Department of Neurology, University of California at Los Angeles (UCLA), and the Veterans Affairs Greater Los Angeles Healthcare System. Drs. Flood and Perlman are affiliated with the University of California at Los Angeles, Los Angeles, California. Address correspondence to Dr. McMurtray; Neurobehavior (166AF), Veterans' Affairs Greater Los Angeles Healthcare, 11301 Wilshire Blvd., Los Angeles, CA 90073; aaronmnm{at}hawaii.edu (E-mail).

ABSTRACT

The spinocerebellar ataxias (SCA) can be manifested in neuropsychiatric symptoms. Among 76 SCA patients presenting to a university ataxia center, depressive symptoms characterized SCA3. Memory symptoms occurred across all SCA groups with relative sparing of SCA6. These differences in neuropsychiatric symptoms suggest the subtype of SCA and the corresponding neuropathological involvement.

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