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Aggression and Quantitative MRI Measures of Caudate in Patients With Chronic Schizophrenia or Schizoaffective Disorder

Drs. Hoptman, Volavka, and Lindenmayer are affiliated with the Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, and the Department of Psychiatry, New York University School of Medicine, New York, New York. Dr. Lindenmayer is also affiliated with the Manhattan Psychiatric Center, New York, New York. Drs. Czobor and Citrome are affiliated with the Nathan S. Kline Institute for Psychiatric Research and Dov Pharmaceuticals, Hackensack, New Jersey. Drs. Gerig and Lieberman are affiliated with the University of North Carolina, Chapel Hill, North Carolina. Dr. Chakos is affiliated with SUNY Downstate Medical Center, Brooklyn, New York. Dr. Bilder is affiliated with the Department of Psychiatry, University of California at Los Angeles, Los Angeles, California. Address correspondence to Dr. Hoptman, 140 Old Orangeburg Rd., Building 35, Orangeburg, NY 10962; Hoptman{at}nki.rfmh.org (E-mail).

Caudate dysfunction is implicated in schizophrenia. However, little is known about the relationship between aggression and caudate volumes. Forty-nine patients received magnetic resonance imaging scanning in a double-blind treatment study in which aggression was measured. Caudate volumes were computed using a semiautomated method. The authors measured aggression with the Overt Aggression Scale and the Positive and Negative Syndrome Scale. Larger caudate volumes were associated with greater levels of aggression. The relationship between aggression and caudate volumes may be related to the iatrogenic effects of long-term treatment with typical antipsychotic agents or to a direct effect of schizophrenic processes on the caudate.

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