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Recent Neuroimaging Techniques in Mild Traumatic Brain Injury

Received September 27, 2005; revised April 12, 2006; accepted April 24, 2006. Dr. Belanger is affiliated with the James A. Haley Veterans Hospital, the Defense and Veterans Brain Injury Center, and the Department of Psychology, University of South Florida, Tampa, Florida. Drs. Vanderploeg and Curtiss are affiliated with the James A. Haley Veterans Hospital, the Defense and Veterans Brain Injury Center, and the Departments of Psychology and Psychiatry, University of South Florida. Dr. Warden is affiliated with the Defense and Brain Injury Center and Walter Reed Army Medical Center, Washington, D.C. Address correspondence to Dr. Belanger, James A. Haley Veterans Hospital, 13000 Bruce B. Downs Boulevard., Tampa, FL 33612; Heather.Belanger{at}va.gov (e-mail).

Mild traumatic brain injury (TBI) is characterized by acute physiological changes that result in at least some acute cognitive difficulties and typically resolve by 3 months postinjury. Because the majority of mild TBI patients have normal structural magnetic resonance imaging (MRI)/computed tomography (CT) scans, there is increasing attention directed at finding objective physiological correlates of persistent cognitive and neuropsychiatric symptoms through experimental neuroimaging techniques. The authors review studies utilizing these techniques in patients with mild TBI; these techniques may provide more sensitive assessment of structural and functional abnormalities following mild TBI. Particular promise is evident with fMRI, PET, and SPECT scanning, as demonstrated by associations between brain activation and clinical outcomes.

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