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Neuropsychiatric Features in 36 Pathologically Confirmed Cases of Corticobasal Degeneration

>Received November 26, 2005; revised May 3, 2006; accepted May 30, 2006. Drs. Geda Boeve, Negash, Knopman, Parisi, and Petersen are affiliated with the Mayo Clinic College of Medicine, Rochester, Minnesota. Drs. Graff-Radford and Dickson are affiliated with the Mayo Clinic College of Medicine, Jacksonville, Florida. Address correspondence to Dr. Geda, Department of Psychiatry, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905; geda.yonas{at}mayo.edu (e-mail).

ABSTRACT

The authors investigated neuropsychiatric features in 36 pathologically confirmed cases of corticobasal syndrome. Depression, compulsive behavior, and frontal lobe-type behavioral alterations were noted in eight patients (22%). No patient experienced visual hallucinations. If confirmed by a prospective study, the absence of visual hallucinations may help to distinguish corticobasal syndrome from other parkinsonian syndromes.

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