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Neurological Signs and Cognitive Performance Distinguish Between Adolescents With and Without Psychosis

Received February 1, 2006; revised May 13, 2006; accepted August 21, 2006. From the University of Colorado School of Medicine, Denver, Colorado. Address correspondence to Dr. Arciniegas, Neuropsychiatry Service, University of Colorado School of Medicine, Campus Box C268-25, 4200 East Ninth Avenue, Denver, CO 80262; David.Arciniegas{at}UCHSC.edu (e-mail)

Neurological and cognitive aspects of adolescent psychotic disorders are understudied. The authors assessed 19 adolescents with psychosis and 16 healthy comparison subjects using the Neurological Evaluation Scale (NES) and age-appropriate Wechsler intelligence quotient (IQ) scales. NES scores were highest and IQ scores were lowest among subjects with psychosis. Subjects with psychosis did not demonstrate age-related decreases in NES score. The combination of NES and IQ scores predicted both the presence of psychosis and psychiatric diagnosis. There were no relationships between medication status and either NES or IQ scores. These results support a broadly conceived neurodevelopmental formulation of adolescent psychotic disorders.

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