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The Effect of Divalproex Sodium on HIV Replication In Vivo

Received April 4, 2006; revised September 3, 2006; accepted September 26, 2006. Drs. Maggi and Halman are affiliated with St. Michael’s Hospital, Mental Health Service, and the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Dr. Halman is also affiliated with St. Michael’s Hospital, Centre for Research in Inner City Health, and St. Michael’s Hospital, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada. Address correspondence to Dr. Maggi, Room 17-033, Cardinal Carter Wing, St. Michael’s Hospital, 30 Bond Street, Toronto, ON M5B 1W8; maggij{at}smh.toronto.on.ca

In vitro data suggest valproate activates HIV replication. This study prospectively assesses whether divalproex sodium causes an increase in HIV replication in patients. Eight participants had their HIV viral load measured over approximately 1 month. The largest increases in viral load occurred in patients without antiretroviral medication. No patients had an increase in Log₁₀ HIV viral load 0.5. Further study is needed to understand implications.

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