Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via Google Scholar Articles by Goyal, N. Articles by Desarkar, P. Search for Related Content PubMed Citation Articles by Goyal, N. Articles by Desarkar, P. Schizophrenia Spectrum Disorders Other Neuroimaging

Efficacy of Adjuvant High Frequency Repetitive Transcranial Magnetic Stimulation on Negative and Positive Symptoms of Schizophrenia: Preliminary Results of a Double-Blind Sham-Controlled Study

Received May 30, 2006; revised June 29, 2006; accepted October 17, 2006. Drs. Goyal, Nizamie, and Desarkar are affiliated with the Adult Psychiatry Unit, Central Institute of Psychiatry, Ranchi, Jharkhand, India. Address correspondence to Dr. Desarkar, Department of Child and Adolescent Psychiatry, Central Institute of Psychiatry, Kanke (PO), Ranchi-834006, Jharkhand, India; pushpalds{at}yahoo.com (e-mail).

ABSTRACT

The potential effect of repetitive transcranial magnetic stimulation (rTMS) on core positive and negative symptoms in schizophrenia has not yet been clearly established. The aim of this study was to examine the efficacy of adjuvant 10 Hz, suprathreshold left prefrontal rTMS in negative symptoms of schizophrenia in a double-blind sham-controlled design. Additionally, our study also investigated the suitability of applying the same stimulus condition on positive symptoms. Ten right-handed schizophrenia patients received sham or active 10 Hz suprathreshold rTMS to the left dorsolateral prefrontal cortex with psychopathology, depression and global improvement ratings before and after rTMS sessions. Compared to sham, active rTMS significantly improved negative symptoms, irrespective of change in depressive symptoms.

Get information about faster international access.

Privacy Policy

Copyright © 2007 American Neuropsychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us