|
| | |
|
J Neuropsychiatry Clin Neurosci 1990; 2:373-384
Copyright © 1990 by American Neuropsychiatric Association
Subgroups in dementia of the Alzheimer type identified using positron emission tomography
CL Grady, JV Haxby, MB Schapiro, A Gonzalez-Aviles, A Kumar, MJ Ball, L Heston and SI Rapoport
Laboratory of Neurosciences, National Institute on Aging, Bethesda, Maryland 20892.
We examined patterns of cerebral glucose metabolism in 33 patients with
dementia of the Alzheimer type by applying principal component analysis to
identify subgroups. Four subgroups were identified: one with predominant
parietotemporal hypometabolism (15 patients); one with paralimbic metabolic
deficits (8 patients); one with left hemisphere neocortical abnormality (5
patients); and one with frontal and parietotemporal deficit (5 patients).
Differences among the subgroups were found in neuropsychological
impairments and prevalence of psychiatric symptoms. These metabolic
subgroups could not be explained on the basis of dementia severity, illness
duration, or age, but were most likely related to an underlying pathology
with a variable regional distribution.
This article has been cited by other articles:
|
|
|
|
 
D. R. Royall, L. K. Chiodo, C. Mouton, and M. J. Polk
Cognitive Predictors of Mortality in Elderly Retirees: Results From the Freedom House Study
Am J Geriatr Psychiatry,
March 1, 2007;
15(3):
243 - 251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. B. Patwardhan, D. C. McCrory, D. B. Matchar, G. P. Samsa, and O. T. Rutschmann
Alzheimer Disease: Operating Characteristics of PET-- A Meta-Analysis
Radiology,
April 1, 2004;
231(1):
73 - 80.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Sultzer, C. V. Brown, M. A. Mandelkern, M. E. Mahler, M. F. Mendez, S. T. Chen, and J. L. Cummings
Delusional Thoughts and Regional Frontal/Temporal Cortex Metabolism in Alzheimer's Disease
Am J Psychiatry,
February 1, 2003;
160(2):
341 - 349.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Neugroschl and K. L. Davis
Biological Markers in Alzheimer Disease
Am J Geriatr Psychiatry,
December 1, 2002;
10(6):
660 - 677.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. L. Grady, M. L. Furey, P. Pietrini, B. Horwitz, and S. I. Rapoport
Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease
Brain,
April 1, 2001;
124(4):
739 - 756.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. L. Lopez, G. Smith, J. T. Becker, C. C. Meltzer, and S. T. DeKosky
The Psychotic Phenomenon in Probable Alzheimer's Disease : A Positron Emission Tomography Study
J Neuropsychiatry Clin Neurosci,
February 1, 2001;
13(1):
50 - 55.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. Meguro, X. Blaizot, Y. Kondoh, C. Le Mestric, J. C. Baron, and C. Chavoix
Neocortical and hippocampal glucose hypometabolism following neurotoxic lesions of the entorhinal and perirhinal cortices in the non-human primate as shown by PET: Implications for Alzheimer's disease
Brain,
August 1, 1999;
122(8):
1519 - 1531.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. B. Colling
Passive behaviors in Alzheimer' disease: A descriptive analysis
American Journal of Alzheimer's Disease and Other Dementias,
January 1, 1999;
14(1):
27 - 40.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. T. Chen, D. L. Sultzer, C. H. Hinkin, M. E. Mahler, and J. L. Cummings
Executive Dysfunction in Alzheimer's Disease: Association With Neuropsychiatric Symptoms and Functional Impairment
J Neuropsychiatry Clin Neurosci,
November 1, 1998;
10(4):
426 - 432.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
N. Hirono, E. Mori, K. Ishii, H. Kitagaki, M. Sasaki, Y. Ikejiri, T. Imamura, T. Shimomura, M. Ikeda, and H. Yamashita
Alteration of Regional Cerebral Glucose Utilization With Delusions in Alzheimer's Disease
J Neuropsychiatry Clin Neurosci,
November 1, 1998;
10(4):
433 - 439.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
D. R Royall, J. A Cordes, and M. Polk
CLOX: an executive clock drawing task
J. Neurol. Neurosurg. Psychiatry,
May 1, 1998;
64(5):
588 - 594.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Lavenu, F. Pasquier, F. Lebert, B. Jacob, and H. Petit
Association between medial temporal lobe atrophy on CT and parietotemporal uptake decrease on SPECT in Alzheimer's disease
J. Neurol. Neurosurg. Psychiatry,
October 1, 1997;
63(4):
441 - 445.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Grossman, F. Payer, K. Onishi, T. White-Devine, D. Morrison, M. D'Esposito, K. Robinson, and A. Alavi
Constraints on the cerebral basis for semantic processing from neuroimaging studies of Alzheimer's disease
J. Neurol. Neurosurg. Psychiatry,
August 1, 1997;
63(2):
152 - 158.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Algase, C. Beck, A. Kolanowski, A. Whall, S. Berent, K. Richards, and E. Beattie
Need-driven dementia-compromised behavior: An alternative view of disruptive behavior
American Journal of Alzheimer's Disease and Other Dementias,
November 1, 1996;
11(6):
10 - 19.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. I. Rapoport
Functional brain imaging to identify affected subjects genetically at risk for Alzheimer's disease
PNAS,
May 23, 2000;
97(11):
5696 - 5698.
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1990
American Neuropsychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
