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Restless Legs Syndrome is Associated with DSM-IV Major Depressive Disorder and Panic Disorder in the Community

Received October 13, 2006; revised January 22 and February 27, 2007; accepted March 5, 2007. Drs. Lee and Lyketsos are affiliated with the Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences at the Johns Hopkins University School of Medicine in Baltimore, Maryland; Dr. Hening is affiliated with the Department of Neurology at the University of Medicine and Dentistry of New Jersey/RW Johnson Medical School in New Brunswick, New Jersey; Drs. Allen and Earley are affiliated with the Department of Neurology at Johns Hopkins University School of Medicine in Baltimore, Maryland; Drs. Kalaydjian and Eaton are affiliated with the Department of Mental Health at the Bloomberg School of Public Health, Johns Hopkins University in Baltimore, Maryland. Address correspondence to Hochang Benjamin Lee, M.D., Assistant Professor of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Osler 320, 600 N. Wolfe St., Baltimore, MD 21287; Hochang{at}jhmi.edu (e-mail).

ABSTRACT

The authors examined the association between restless legs syndrome (RLS) and DSM-IV major depressive disorder and panic disorder based on Wave III and IV of the Baltimore ECA follow-up study. Of 1071 participants, 1024 completed the RLS Questionnaire and Diagnostic Interview Schedule. Adjusted odds ratio for diagnosis of major depressive disorder (4.7, 95% confidence interval [1.6, 14.5]) and panic disorder (12.9 [3.6, 46.0]) and comorbidity of major depressive disorder and panic disorder (9.7 [1.4, 69.0]) in the past 12 months suggested a strong association between restless legs syndrome and major depressive disorder and/or panic disorder.

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