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Traumatic Brain Injury, Apolipoprotein E-4, and Cognition in Older Adults: A Two-Year Longitudinal Study

Received September 28, 2006; revised February 14, 2007; accepted April 2, 2007. The authors are affiliated with the Sunnybrook Health Sciences Centre - Geriatric Psychiatry, Toronto, Ontario, Canada. Address Correspondence to Mark Rapoport, FG37-2075 Bayview Ave., Toronto, ON, M4N 3M5; mark.rapoport{at}sunnybrook.ca (e-mail).

Patients with mild-to-moderate traumatic brain injury (TBI) (N=69) were compared with age-, gender-, and education-matched healthy control group subjects (N=79) on performance of neuropsychological tests at one and 2 years following injury, and informant-rated functional abilities. All subjects were assessed for the presence of the Apolipoprotein E-4 (APOE-4) allele and rated for "mild cognitive impairment" (MCI) or dementia. Traumatic brain injury patients were no different from the comparison group on measures of cognition or functional impairment. Traumatic brain injury was not associated with higher rates of amnestic mild cognitive impairment or dementia, and APOE-4 was not associated with cognition.

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