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Electroencephalographic Cerebral Dysrhythmic Abnormalities in the Trinity of Nonepileptic General Population, Neuropsychiatric, and Neurobehavioral Disorders

Received December 30, 2006; revised April 21, 2007; accepted May 25, 2007. Dr. Shelley is affiliated with the Raymond Way Neuropsychiatry Research Group at the Institute of Neurology at Queen Sq., London; Dr. Trimble is affiliated with the Institute of Neurology at Queen Square, London; Dr. Boutros is affiliated with Wayne State University School of Medicine in Detroit, Michigan. Address correspondence to Dr. Bhaskara P. Shelley, MBBS, M.D., D.M., Head, Department of Neurology, Father Muller Medical College, Karnataka, Mangalore-575 002, India; bpshelley{at}yahoo.com (e-mail).

Subclinical electroencephalographic epileptiform discharges in neurobehavioral disorders are not uncommon. The clinical significance and behavioral, diagnostic, and therapeutic implications of this EEG cerebral dysrhythmia have not been fully examined. Currently the only connotation for distinctive epileptiform electroencephalographic patterns is epileptic seizures. Given the prevailing dogma of not treating EEGs, these potential aberrations are either disregarded as irrelevant or are misattributed to indicate epilepsy. This article reappraises the literature on paroxysmal EEG dysrhythmia in normative studies of the "healthy" nonepileptic general populations, neuropsychiatry, and in neurobehavioral disorders. These EEG aberrations may be reflective of underlying morpho-functional brain abnormalities that underpin various neurobehavioral disturbances.

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